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KMID : 1812020130190040426
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Journal of Neurogastroenterology and Motility
2013 Volume.19 No. 4 p.426 ~ p.432
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Ionic Conductance(s) in Response to Post-junctional Potentials
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Abstract
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The gastrointestinal motility is regulated by extrinsic and intrinsic neural regulation. Intrinsic neural pathways are controlled by sensory input, inter-neuronal relay and motor output. Enteric motor neurons release many transmitters which affect post-junc-tional responses. Post-junctional responses can be excitatory and inhibitory depending on neurotransmitters. Excitatory neuro-transmitters induce depolarization and contraction. In contrast, inhibitory neurotransmitters hyperpolarize and relaxe the gas-trointestinal smooth muscle. Smooth muscle syncytium is composed of smooth muscle cells, interstitial cells of Cajal and plate-let-derived growth factor receptor ?-positive (PDGFR?+) cells (SIP syncytium). Specific expression of receptors and ion channels in these cells can be affected by neurotransmitters. In recent years, molecular reporter expression techniques are able to study the properties of ion channels and receptors in isolated specialized cells. In this review, we will discuss the mechanisms of ion channels to interpret the post-junctional responses in the gastrointestinal smooth muscles.
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KEYWORD
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Gastrointestinal motility, Ionic conductance, Post-junctional potentials
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